Gemcitabine modulation of alkylator therapy
نویسندگان
چکیده
منابع مشابه
Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways.
Activation of signal transducer and activator of transcription 3 (STAT3) is associated with poor clinical outcome of glioblastoma (GBM). However, the role of STAT3 in resistance to alkylator-based chemotherapy remains unknown. Here, we retrospectively analyzed the phosphorylated STAT3 (p-STAT3) profile of 68 GBM patients receiving alkylator therapy, identifying p-STAT3 as an independent unfavor...
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Primary systemic therapy (ie, preoperative or neoadjuvant) increases the possibility for breast-conserving surgery in patients with primary breast cancer. Patients with pathologic complete response to primary systemic therapy have improved survival compared with those with persistent tumors. Several phase II trials have evaluated gemcitabine-containing doublet or triplet regimens as primary sys...
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Alkylating chemotherapy is the mainstay in the treatment of pediatric and adult glioblastoma despite primary and acquired resistance and scientific efforts to precisely define therapies for individual patients. A focus on non-MGMT-mediated temozolomide resistance for pediatric glioblastoma suggests options for new drug combinations.
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CORRESPONDENCE Circannua11y herpetic eye attacks: questionable significant rhythmicities EDIToR,-Gamus et alt have reported significant circannual rhythms of epithelial herpetic keratitis in males, especially in the age groups 6-10 years and 45 years and older. No such rhythms were found in females. If the authors of the paper had made additional subdivisions , again according to age, sex, and ...
متن کاملBevacizumab for recurrent alkylator-refractory anaplastic oligodendroglioma.
BACKGROUND A retrospective evaluation of single agent bevacizumab was carried out in adults with recurrent alkylator-refractory 1p19q codeleted anaplastic oligodendrogliomas (AO) with an objective of determining progression-free survival (PFS). There is no standard therapy for alkylator-resistant AO, and hence a need exists for new therapies. METHODS Twenty-two patients aged 24 to 60 years wi...
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ژورنال
عنوان ژورنال: Cancer
سال: 2001
ISSN: 0008-543X
DOI: 10.1002/1097-0142(20010701)92:1<194::aid-cncr1309>3.0.co;2-3